Introduction

• Collection of in-vivo PDX models (procedures were approved by Animal Care Committees, according to ethical guidelines for animal care and handling)
• Collection of in-vitro derived cell lines,
• 2D & 3D ex-vivo assays,
• In-vivo humanized models (immune system, liver and tumour stroma),
• Characterization of tumour histology, gene mutations, gene expression, pharmacological responses and gut microbiota,
• Biobanks of tumours, blood, serum and stools (patient specimens were obtained from 7 clinical centers with written informed patient consent for providing surgical tumor samples and for HIV1&2, HTLV1&2, HBV and HCV serological status testing),
• Central database,
• Datamining,