Olivier DUCHAMP, IMODI coordinator, co-author of the book: Patient Derived Tumor Xenograft Models

New results on the mechanism of drug resistance in AML (Acute Myeloid Leukemia) published in Cancer Discovery by the Team RESISTAML (INSERM U1037) headed by Dr. Jean-Emmanuel Sarry, IMODI Partner
Auragen a gene sequencing project carried by the actors of the French Auvergne Rhône-Alpes region

Olivier DUCHAMP, IMODI coordinator, co-author of the book: Patient Derived Tumor Xenograft Models

Patient Derived Tumor Xenograft Models

Promise, Potential and Practice

Edited by Rajesh Uthamanthil, Peggy Tinkey
Associate Editor : Elisa de Stanchina

A reference guide for development and use of PDX models

Patient Derived Tumor Xenograft Models: Promise, Potential and Practice offers guidance on how to conduct PDX modeling and trials, including how to know when these models are appropriate for use, and how the data should be interpreted through the selection of immunodeficient strains.

In addition, proper methodologies suitable for growing different type of tumors, acquisition of pathology, genomic and other data about the tumor, potential pitfalls, and confounding background pathologies that occur in these models are also included, as is a discussion of the facilities and infrastructure required to operate a PDX laboratory.

  • Offers guidance on data interpretation and regulatory aspects
  • Provides useful techniques and strategies for working with PDX models
  • Includes practical tools and potential pitfalls for best practices
  • Compiles all knowledge of PDX models research in one resource
  • Presents the results of first ever global survey on standards of PDX development and usage in academia and industry


We need to consider the entirety of the cancer pathology and not only the tumor epithelial cells. Moreover, the diversity of models, the costs of model development, PDX collection maintenance, and quality control of all these collections seems also to be a big challenge in the near future..

Collaborative program director
IMODI Coordinator


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