Edited by Rajesh Uthamanthil, Peggy Tinkey
Associate Editor : Elisa de Stanchina
Patient Derived Tumor Xenograft Models: Promise, Potential and Practice offers guidance on how to conduct PDX modeling and trials, including how to know when these models are appropriate for use, and how the data should be interpreted through the selection of immunodeficient strains.
In addition, proper methodologies suitable for growing different type of tumors, acquisition of pathology, genomic and other data about the tumor, potential pitfalls, and confounding background pathologies that occur in these models are also included, as is a discussion of the facilities and infrastructure required to operate a PDX laboratory.
We need to consider the entirety of the cancer pathology and not only the tumor epithelial cells. Moreover, the diversity of models, the costs of model development, PDX collection maintenance, and quality control of all these collections seems also to be a big challenge in the near future..
Collaborative program director