Symposium Tumor microenvironment

Understand the dynamics that bind tumor cells and their "nest" generating either their proliferation or their destruction.

Friday 1st February 2019
Institut Servier – Suresnes - France

In recent years, research on the interaction between the tumor and its microenvironment has become a major focus in understanding cancer development in order to provide ad hoc models for personalized treatment that tends to be more effective.

A growing tumor is composed not only of cancer cells but also contains stromal cells (fibroblasts, endothelial cells and immune cells) and extracellular matrix components that are collectively referred to as the “Tumor Microenvironment”. Moreover, preclinical and clinical data highlighted a link between cancer development, anticancer immunity, treatment efficacy and intestinal microbiota.

The tumor microenvironment has great effects on how tumor cells begin and expand as aggressive and metastatic diseases. We know that the tumor microenvironment play a major role in the treatment response and the development of therapeutic resistance.

We will discuss throughout the day how the tumor microenvironment has an impact on cancer development.  We will go through some models and tools, which have been developed within the consortium IMODI, to reconstitute cancer microenvironment in the aim to devise strategies targeting the tumor microenvironment to improve cancer treatments.


Final Programme

Understand the dynamics that bind tumor cells and their "nest" generating either their proliferation or their destruction.

  • 10h00-10h30   Introduction (Olivier DUCHAMP)
  • Role and modeling of the immune system
  • 10h30-11h05   Biomarkers in immuno oncology (Christophe CAUX)
  • 11h05-11h40   How to better predict the effect of cancer immunotherapy: tailored-made humanized mouse models is the key solution (Caroline MIGNARD)
  • 11h40-11h55   Coffee break
  • 11h55-12h30   Use of the iPS cell technology for development of PDX models with an autologous human immune system (Pauline WAJDA)
  • 12h30-13h05   Microenvironment and leucemic cells in in vivo therapeutic resistance (JE Sarry‘s team)
  • 13h05-14h15   Lunch
  • Hepatic environment
  • 14h15-14h50   Humanized liver and immune system mice: an overview (Floriane FUSIL)
  • Microbiota
  • 14h50-15h25   Microbiota and Cancer: Driver or Biomarker? (Françoise LE VACON)
  • Stroma & cancer
  • 15h25-16h00   Development of patient-derived models to study tumor - stroma crosstalks in pancreatic cancer (Corinne BOUSQUET)
  • 16h00-16h15   Coffee break
  • 16h15-16h50   Cellular models & 3D printing (Olivier DEGOUL)
  • Biomarkers
  • 16h50-17h25   Artificial Intelligence and identification of biomarkers for precision medicine (Mohammad AFSHAR)
  • 17h25-17h45   Conclusion (Olivier DUCHAMP)

How to register?



Institut Servier

  • 53 rue Carnot
    92284 SURESNES cedex
    Building 3 on the access map